Chemically, ofloxacin has three condensed 6membered rings made up of a fluorinated carboxyquinolone with a benzoxazine ring. When a new sds is obtained for a product, remove the earlier version and replace it with the new one, however, do not discard the older version. Material safety datasheet 9sections section 1 product information product identifier drytype transformer whmis classification optional product use electrical manufacturers name. Ofloxacin has been linked to rare instances of acute hepatocellular injury. The comparisons of ciprofloxacin versus cefixime and ofloxacin versus cefixime were each based on one trial. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
This indicates a small degree of biliary excretion of ofloxacin. Collect powder using special dust vacuum cleaner with particle filter or carefully sweep into suitable waste disposal containers and seal securely. Studies indicate that less than 5% of an administered dose is recovered in the urine as the desmethyl or noxide metabolites. First aid measures material safety data sheet material levofloxacin tablets 250 mg, 500 mg and 750 mg manufacturer lupin limited goa 403 722 india. Page 16 safety data sheet according to 19072006ec, article 31 printing date 02. Safety data sheet creation date mar2014 revision date 23jan2018 revision number 5 1. Ofloxacin 200 mg tablets summary of product characteristics. Ten lactating women time postpartum not stated were given ofloxacin. Select pdf files from your computer or drag them to the drop area. Compress pdf files for publishing on web pages, sharing in social networks or sending by email. View indentification, hazards, safety information, toxicity, regulations. Like other fluoroquinolones, ofloxacin inhibits dna gyrase and.
Norfloxacin is a synthetic, broadspectrum fluoroquinolone with antibacterial activity. Ofloxacin, like other 4quinolones, is unusual among front line drugs available to treat bacterial infections since it affects bacterial dna synthesis, rather than cell wall or protein synthesis 2. The sds file should be an active file and should be updated whenever a new chemical is introduced in the work area or a revision occurs. This document has been prepared in accordance with standards for workplace safety, which require the inclusion of all known hazards of the active substance or.
Hazards identification general advice consult a physician. Msds document numbern000 revision dated 03 sept 96 in an emergency, call chemtrec at 8004249300 us. When a new sds is obtained for a product, remove the earlier version. Identification of the substancemixture and of the companyundertaking 1. The original intent of the ghs was to bring some consistency and coherency to the hazard information available to workers. Ofloxacin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and serum samples by chromatography and spectrophotometry techniques. The safety data sheets sdss are intended to provide health, safety and environmental information for the people handling these products. Material safety data sheet of ofloxacin contains identification of substance and details of the supplier of the safety data sheet. Nitrogen msds material safety data sheet for nitrogen n2 reference. Rapidly and almost completely absorbed from gi tract.
Identification of the substancemixture and of the companyundertaking product name. Understanding and correcting msds file upload errors. Absorption of ofloxacin after single or multiple doses of 200 to 400 mg is predictable, and the amount of drug absorbed increases proportionately with the dose. Hazard determinations as specified at 29 cfr, part 1910. In individual cases it may be necessary to increase the dose to. Technical data sheet ofloxacin name of product ofloxacin product date 2012. When taken by mouth or injection into a vein, these include pneumonia, cellulitis, urinary tract infections, prostatitis, plague, and certain types of infectious diarrhea. Show this safety data sheet to the doctor in attendance.
Synthesis and antibacterial activities of optically active. Ofloxacin united states pharmacopeia usp reference standard cas number 82419361. Methods and material for containment and cleaning up methods for cleaning up wear protective clothing as described in section 8 of this safety data sheet. Exceptions to the recognized standard of clsi m100.
Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting dna gyrase bacterial topoisomerase ii, an enzyme required for dna replication, rna transcription, and repair of. Ofloxacin is an oxazinoquinolone carrying carboxy, fluoro, methyl and 4methylpiperazino substituents. Ofloxacin is known to be excreted into breast milk after systemic administration. These secondary standards are qualified as certified reference materials. Ofloxacin united states pharmacopeia usp reference. Page 16 safety data sheet according to 19072006ec, article 31 printing date. Download msdsmaterial safety data sheet of enrofloxacin. Ofloxacin ophthalmic solution ofloxacin ophthalmic solution. Generally, individual doses should be given at approximately equal intervals. Jul 14, 2017 ocuflox solution is unbuffered and formulated with a ph of 6. Material safety data sheets msdss, the original versions of. Other companies are charging thousands of dollars to set up accounts. Ofloxacin is a fluoroquinolone florokwinolone antibiotic that fights bacteria in the body.
Lipitor atorvastatin calcium tablets pfizer inc believes that the information contained in this material safety data sheet is accurate, and while it is provided in good faith, it material name. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Cefpodoxime proxetil tablets 100 mg and 200 mg revision date. Find patient medical information for ofloxacin oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Ofloxacin cas 82419361 scbt santa cruz biotechnology. Unlike other services this tool doesnt change the dpi, thus keeping your documents printable and zoomable. It is a fluorinated carboxyquinolone antiinfective for topical ophthalmic use. College of pharmacy, chitradurga, karnataka india abstract ofloxacin. Formulation and evaluation of ofloxacin aqueous injection. Formulation and evaluation of ofloxacin aqueous injection 1, t. Serious adverse reactions fluoroquinolones, including ofloxacin, have been associated with disabling and potentially irreversible serious adverse reactions e. Empirical formula hill notation c 18 h 20 fn 3 o 4. Cepi helpful hints understanding and correcting msds file upload errors page 1 of 10 last updated march 31, 2016 understanding and correcting msds file upload errors during the file upload process in msds, users will often receive a popup message indicating the file.
Four to eight percent of an ofloxacin dose is excreted in the feces. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. The dosage range for adults is 200 mg to 800 mg daily. Up to 400 mg may be given as a single dose, preferably in the morning. Levofloxacin is a broadspectrum, thirdgeneration fluoroquinolone antibiotic and optically active lisomer of ofloxacin with antibacterial activity. Ofloxacin is an antibiotic useful for the treatment of a number of bacterial infections. Ofloxacin has in vitro activity against a broad range of grampositive and gramnegative aerobic and anaerobic bacteria. Material safety data sheet material levofloxacin tablets 250 mg, 500 mg and 750 mg manufacturer lupin limited goa 403 722 india distributor lupin pharmaceuticals, inc. Floxin ofloxacin tablets tablets is a synthetic broadspectrum antimicrobial agent for oral administration. Full text is available as a scanned copy of the original print version. The information provided in this safety data sheet is correct to the best of our knowledge, information and belief at the date of its publication. Enrofloxacin msds pdf baytril 10% injectable solution. Ofloxacin is a second generation fluoroquinolone antibiotic. Ofloxacin is used to treat bacterial infections of the skin, lungs, prostate, or urinary tract bladder and kidneys.
Sigmaaldrich offers a number of ofloxacin products. In fertility studies in rats, ofloxacin did not affect male or female fertility or morphological or reproductive performance at oral dosing up to 360. The dose of ofloxacin is determined by the type and severity of the infection. Norfloxacin inhibits activity of dna gyrase, thereby blocking bacterial dna replication. Links to pubmed are also available for selected references. Capitals indicate lifethreatening, underlines indicate most frequent. Sds msds database search safety data sheets library. Ofloxacin is also sometimes used to treat other types of infection, including legionnaires disease type of lung infection, certain sexually transmitted diseases, infections of the bones and joints and of the stomach and intestines. Ofloxacin 20 mgkg, norfloxacin 40 mgkg, pefloxacin mesylate dihydrate 40 mgkgand ciprofloxacin 50 mgkg were administered by gavage. Minimum inhibitory concentrations mcgml disk diffusion zone diameter in mm. Following is a list of allergan products for which material safety data sheets msds are not required. A synthetic fluoroquinolone antibacterial agent, it inhibits the supercoiling activity of bacterial dna. The sds includes information such as the properties of each chemical. If inhaled if breathed in, move person into fresh air.
The selection and use of essential medicines world health. Ofloxacin is a fluorinated 4quinolone which differs from other fluorinated 4quinolones in that there is a six member pyridobenzoxazine ring from positions 1 to 8 of the basic ring structure. Ofloxacin is an antibiotic prescribed to treat pneumonia, bronchitis, staph infections, stds gonorrhea, chlamydia, urinary tract infections, and prostate infections caused by e. Disclaimer the sds samples above are collected from the internet by chemblink and displayed here for the tutorial purpose only. Ofloxacin is bactericidal at concentrations equal to or slightly greater than inhibitory concentrations. For research use only, not for human or veterinary use. Accidental release measures contain spill and collect, as appropriate. Page 3 of 5 7 handling and storage precautions for safe handling. Fluka n9890 page1 of 6 sigmaaldrich safety data sheet according to regulation ec no.
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